Effects of L-NAME on Antinociceptive Induced by Morphine in Formalin Test
نویسندگان
چکیده
منابع مشابه
The Effect of L-NAME on Morphine Antinociception in Formalin Test
Introduction: N- nitro-L-arginine methyl ester (L-NAME), one of the L-arginine analogs, has been specified as an inhibitor of nitric oxide synthase ( NOS).Nitric oxide synthase is an enzyme which leads to nitric oxide synthesis. Since nitric oxide has been known as a pain mediator, it can be said that L-NAME can decrease and relieve pain. In this research the effect of L-NAME on morphine antino...
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In this study, the antinociceptive effects of the gap junction blocker carbenoxolone and morphine were examined using the formalin test as a model of pain. We found that carbenoxolone was dose-dependently antinociceptive in both the first and second phases of the formalin test. Pretreatment with carbenoxolone increased antinociceptive effect of morphine in the first phase of formalin test. Also...
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ژورنال
عنوان ژورنال: Asian Journal of Animal and Veterinary Advances
سال: 2006
ISSN: 1683-9919
DOI: 10.3923/ajava.2007.15.20